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What is UPOINT?
The ‘UPOINT’ phenotyping classification system has been developed with 6 discrete, relevant and identifiable phenotypic domains:6
Urinary domain includes patients reporting bothersome urinary frequency, urgency, nocturia, incontinence and/or dysuria. It is expected that most, if not all patients, would be included in this domain due to the criteria that is used clinically to make the diagnosis of PBS/IC.
Psychosocial domain includes patients identified as being clinically depressed (or with recent history of depression), those with identifiable maladaptive coping mechanisms, or problems with social interactions. This can be based on a simple clinical assessment with standard history and focused interview.
Organ specific domain includes patients who report pain with bladder recycling (typically pain with bladder filling and temporary relief with voiding), pain on bladder filling detected with low volumes of irrigation fluid, glomerulations and/or Hunner's ulcers noted during cystoscopy (either local or general anaesthesia) and/or patients with typical inflammation confirmed on bladder biopsy.
Infection domain includes patients who have confirmed significant bacteriuria with typical uropathogenic bacteria within the previous year or so associated with an exacerbation in baseline symptoms and return to baseline symptoms following appropriate antimicrobial therapy. It must be emphasised that a diagnosis of PBS/IC can only be made when symptoms persist in the face of sterile urine.
Neurologic/Systemic domain includes patients with a concurrent diagnosis of irritable bowel syndrome, fibromyalgia, chronic fatigue syndrome, vulvodynia or any other condition that suggests neuropathy or neural up-regulation.
Tenderness domain includes patients who are noted to have pelvic floor muscle/ligament tenderness and/or pain, including but not restricted to specific trigger points during standardised pelvic examination.
Each domain can then be managed by a therapeutic intervention which addresses the specific pain or symptom presented.
Reference - http://www.unravellingtheenigma.co.uk/Galen_Report.pdf