Where am I: Product information > Optimum dose of chondroitin sulfate

Optimum dose of chondroitin sulfate

Uracyst^® may provide the optimum dose of chondroitin sulfate^4,5

Uracyst (2% chondroitin sulfate) is formulated with 5 times more chondroitin sulfate per treatment than the currently available 0.2% formulation of intravesical chondroitin sulfate.

Results from an experimental animal study suggest that the optimum uptake of chondroitin sulfate in the human bladder would be at instillation doses of approximately 300mg.^4,5 This indicates that the dosage provided by Uracyst, i.e. 400mg, should be sufficient for the damaged bladder to reach saturation point of chondroitin sulfate and that 80mg may be insufficient. ^4,5

As can be seen from the graph below, uptake of intravesical chondroitin sulfate by damaged bladder is x 2.6-fold greater at a dose of 400mg compared to 80mg.⁴

These figures are based on values from damaged rat bladder which have been extrapolated to human bladders.

Binding of chondroitin sulfate to acid-damaged bladder⁴

View graph